mRNA translation regulation

What is mRNA Translation Regulation?

Using mRNA biology to treat diseases is a completely different approach to any that has been used in the therapeutics industry ever before. mRNA medicines are different from traditional pharmaceuticals and traditional biologics; they aren’t small molecules or recombinant proteins.

mRNA medicines are a set of instructions that tell the body how to prevent or fight off specific diseases.

What is mRNA?

 mRNA is the messenger of RNA, ribonucleic acid, a molecule responsible for various biologic processes such as coding, decoding, regulating, and expressing genes. mRNA is essential for the body; without it, your genetic code wouldn’t get used, proteins would never get made.

Essentially, without mRNA, your body would not be able to perform all the functions that keep you happy and healthy. The specific role of mRNA is to carry genetic code from the DNA in a cell’s nucleus to the ribosome, which is the bit in the cell responsible for making protein.

How Do mRNA Medicines Work?

mRNA medicines take advantage of mRNA’s natural job to present a set of instructions to influence how cells make proteins and send them around the body.

This new approach to therapeutics opens many doors, with the potential for mRNA drugs to be used to treat diseases that any other technologies cannot address.

mRNA medicines are created in a lab, where the mRNA medicine is encoded with an antigen of the infectious agent. This antigen is made in the lab from a DNA template of the infectious agent.

To increase the stability of the medicine, the mRNA is then enveloped by certain fatty substances. The mRNA medicine is then injected into a patient, where it makes its way to the target cells to promote the creation of an antigen protein which will then trigger the desired immune response.  

 What is mRNA Translation Regulation?

 The age of mRNA therapeutics is here; new technology is emerging to transform the therapeutics industry further. One group of technologies that have the potential to create a big impact are technologies that focus on mRNA translation regulation.

mRNA translation regulation is a key aspect of protein synthesis. Technology can be used to target proteins involved in mRNA translation regulation to identify small molecules that control and govern protein production.

By targeting proteins that regulate the translation process, these technologies utilize small molecules to improve upon the therapeutic shortcomings apparent in the industry.

 The Future of mRNA Therapeutics

 The potential for mRNA therapeutics is a relatively new field in the industry. Only coming onto the global stage in 2020, mRNA technology has managed to have a huge impact on a very small amount of time.

Being viewed by experts as the future for therapeutics, the potential for mRNA medicine is vast. mRNA medicine has proved a hugely effective response to diseases like COVID-19, but this mRNA medicine’s potential does not end there.

Research is currently underway using mRNA biology to treat previously undruggable diseases. With new technologies evolving to target mRNA translation regulation, the potential for mRNA appears almost endless.